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Tamoxifen has been shown to be more beneficial for women whose bre-ast cancer cells contain estrogen receptors (ER). An "ER-positive cell" (One that has estrogen receptors) may contain hundreds or thousands of estrogen receptors near the cell nucleus where the genetic information is stored. Because tamoxifen works by binding to estrogen receptors in cells thus blocking the body'S own supply of estrogen from reaching the receptors, women with ER-positive receptors typically respond better to tamoxifen therapy than women with ER-negative receptors. A tissue sample obtained from bre-ast biopsy may be an-alyzed to determine whether cancer cells are ER-positive or ER-negative. Note: The absence of estrogen receptors in bre-ast cancer cells does not necessarily mean that tamoxifen will be ineffective. Researchers are still investigating how tamoxifen acts on ER-negative cells.
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In the Arimidex study, women taking the aromatase inhibitor had significantly fewer cases of endometrial than women taking tamoxifen. The same was true for other major side effects of tamoxifen. On the other hand, women taking tamoxifen had fewer bone fractures.
"Our results should not be viewed as evidence that fluoxetine can safely be used in combination with tamoxifen," They write. Similarly, the numbers of women taking other SSRIs in combination with tamoxifen may have been too small to reveal any adverse effect on bre-ast cancer survival caused by those drug combinations. However, there are SSRIs that do not interfere with the metabolism of tamoxifen and may be used in women taking tamoxifen.
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This conversion is called aromatization and it relies on the action of the enzyme aromatase. Arimidex prevents aromatization by binding to the aromatase.
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Options. Posted by Kay on 12 Dec 2011 at 10:34 Am Arimidex gave me severe joint and muscle pain. Changed to tamoxifen and it gave me a blood clot. Changed to Aromasin and suffered joint and muscle pain again but not quite as bad as Arimidex. Night sweats are a big problem along with hair loss. I'M only taking it every other day. My oncologist knows that I'Ve chosen to do this. So far I'Ve not had a recurrence four years from a mastectomy.
I had two hip replacements and feel 20 years younger! Was the loss of cartilege from the Arimidex or chemo? The Dr.S say no. I'M not convinced. I hope that when I stop the Arimidex that I lose a few more pounds and continue to be cancer-free.
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Metronidazole belongs to the family of medicines called anti-infectives. It is often used to treat infections and bacterial and trichomonal vaginitis, as well as a wide variety of systemic infections (Including dysentery) and infections of the respiratory tract, bones, joints and stomach. A commonly used brand name of metronidazole is Flagyl. Flagyl is available in oral and parenteral (IV) form and is usually given orally.
You can'T drink alcohol with metronidazole for a period of 48 hours otherwise side effects can occur like hot flushes, abdominal camps and palpitations. Do not drive on heavy machines or drive after taking this drug as it can impair you mental ability. There can be varying amount of drowsiness or dullness in different individuals. Use Flagyl (Metronidazol) carefully in patients having low kidney and liver function, rare blood disorders called porphyrias and hepatic encephalopathy. It is contraindicated in patients having allergy to this kind of drugs. Metronidazole is not to be used in pregnant women as it may harm the growing fetus. This drug is known to pass through mother'S milk. It should be used carefully in bre-astfeeding or lactating mothers. Do not take high dose of this drug while feeding your child. Know more about Flagyl from your medical advisor. Flagyl (Metronidazol) should be taken along with or after the food. It should be swallowed as a whole and you must not chew. Take the drug with water and do not combine it with alcohol or any other drinks. Keep regular interval between two doses otherwise side effects may become predominant.
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Metronidazole alone rarely causes Stevens-Johnson syndrome but is reported to occur at high rates when combined with mebendazole.
Metronidazole is used in veterinary medicine to treat a variety of anaerobic bacterial infections and parasitic diseases in dogs and cats, such as Trichomonas, Giardia, Balatidium. It can also be prescribed for the treatment of inflammatory bowel disease, gum disease, diarrhea, tetanus and symptoms associated with liver disease, among many other conditions.
Flagyl (Metronidazole) for Bacterial Infection: I have used this medication several times for bacterial infections. And they do a great job, but this time I am having a headache everyday I'Ve been using it and an upset stomach, but I guess its worth it to get rid of the infection.
A recent clinical research found out that metronidazole does not inhibit the breakdown of acetaldehyde in the liver and there is no significant increase in blood level of acetaldehyde when metronidazole and alcohol are taken together. The researchers said that a different mechanism may be at work. Karamanakos and colleagues (2007) Suggested that the reactions may be due to increase serotonin level in the brain when Flagyl is taken; they have observed this scenario in the laboratory rats.
Do not use grocery store brands they are full of preservatives and 4d meats (Dead, diseased dying and disabled) and they give the dogs stinky gas and are full of unhealthy fillers. The metronidazole in this combination of medicines mzy cause some peopleto become dizzy or lightheaded. Ultrasonographic findings in dogs and cats with oxalate nephrosis attributed to ethylene glycol intoxicati5 cases (). May 17, 2011,vs metronidazole tinidazole gets its likely to pustules and erythema of brain abscews caused by. Both of these studies support the possibility that metronidazole may have unique activity against an anaerobic sub-population of bacilli in human disease. My metronidazole has just started me on 1500mg inexperience per day. For use in dogs and cats to aid in acidificatuon of the urine.
although it may be difficult to keep all the potential health effects of alcohol straight, the good news is that antibiotics can do a lot of good, as long as you take them as prescribed. In sunlight, metronidazole would make you dizzy, feel sick, and answerable; give you headaches and stomach sarah. Meyler'S side effects of drun encyclopedia of adverse reactions and interactions. But with the "Mother wart" Tissue of tje cervix treated, follow-up treatment can be continued with topical gels the patient herself can use externally on these last remaining hauntings of hpv. Metronidazole side effects dogs There are numerous causes including prolonged illness, using antibiotics, and a poor diet. Metronidazole compete for the electrons with hydrogenase or oxygen, which results in its reduction and release of cytotoxic nitroradicals.
IndicationsMetronidazole is an antibacterial drug prescribed for certain %#&@$!l and urinary tract infections in men and women; amebic dysentery and liver abscess; and infections of the abdomen, skin, bones and joints, brain, lungs, and heart caused by certain bacteria.
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Metronidazole is effective against trichomoniasis during pregnancy, but it may increase the risk of preterm birth. The intervention is clearly feasible in under-resourced settings as metronidazole is relatively inexpensive and available as a generic product.
The MetroGel 1% gel consists of metronidazole in a base of betadex, edetate disodium, hydroxyethyl cellulose, methylparaben, niacinamide, phenoxyethanol, propylene glycol, propylparaben and purified water.
You should also always ensure that you complete the full course of metronidazole as prescribed, even if your symptoms disappear and you feel better. If you stop taking the tablet too early, the bacterial vaginosis infection may not be completely cleared and symptoms may subsequently return.
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If you miss taking your scheduled albuterol, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
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Plavix is used for reducing the risk of stroke or heart attack in patients who have already had a heart attack or stroke, have other circulatory problems caused by narrowing and hardening of the arteries, or have certain other heart problems eg, unstable angina.
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Observational studies of the effect of co-administration of a proton pump inhibitor and clopidogrel on cardiovascular outcomes following acute coronary syndromes have had conflicting findings.
As yet, we have no data assuring that prasugrel is safe to use in combination with fibrinolytic agents, so patients on thrombolytic therapy for acute MI should continue to receive clopidogrel starting immediately after lysis. Furthermore, in patients who proceeded to coronary artery bypass grafting, the rate of major bleeding was more than four times higher in the prasugrel group than in the clopidogrel group in the TRITON-TIMI 38 trial.
CYP2C19 poor metabolizer status is associated with diminished response to clopidogrel. The optimal dose regimen for poor metabolizers has yet to be determined. See CLINICAL PHARMACOLOGY: Pharmacogenetics.
Ticlopidine Ticlid, a first-generation thienopyridine, is also a prodrug, but it is unclear to what extent CYP2C19 enzymatic activity is required for its bioactivation. Prasugrel Effient, a third-generation thienopyridine that was recently approved by the FDA, is also a prodrug, but is unique in that its bioactivation appears to be less dependent on CYP2C19 activity. In fact, carriers of the 2 allele produce equivalent concentrations of active metabolite and achieve similar degrees of platelet inhibition compared with noncarriers.
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