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Tamoxifen has been shown to be more beneficial for women whose bre-ast cancer cells contain estrogen receptors (ER). An "ER-positive cell" (One that has estrogen receptors) may contain hundreds or thousands of estrogen receptors near the cell nucleus where the genetic information is stored. Because tamoxifen works by binding to estrogen receptors in cells thus blocking the body'S own supply of estrogen from reaching the receptors, women with ER-positive receptors typically respond better to tamoxifen therapy than women with ER-negative receptors. A tissue sample obtained from bre-ast biopsy may be an-alyzed to determine whether cancer cells are ER-positive or ER-negative. Note: The absence of estrogen receptors in bre-ast cancer cells does not necessarily mean that tamoxifen will be ineffective. Researchers are still investigating how tamoxifen acts on ER-negative cells.
Very rarely, if the side effects are severe, you may have to stop taking tamoxifen and a different drug may be prescribed.
Tamoxifen transformed bre-ast cancer therapy when it was shown to reduce the risk of cancer coming back by close to 50 percent. But the pill, sold by AstraZeneca under the brand name Nolvadex and also available generically, raises the risk of death from strokes and endometrial cancer.
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In the Arimidex study, women taking the aromatase inhibitor had significantly fewer cases of endometrial than women taking tamoxifen. The same was true for other major side effects of tamoxifen. On the other hand, women taking tamoxifen had fewer bone fractures.
"Our results should not be viewed as evidence that fluoxetine can safely be used in combination with tamoxifen," They write. Similarly, the numbers of women taking other SSRIs in combination with tamoxifen may have been too small to reveal any adverse effect on bre-ast cancer survival caused by those drug combinations. However, there are SSRIs that do not interfere with the metabolism of tamoxifen and may be used in women taking tamoxifen.
Although it is rare, tamoxifen has been known to cause cataracts in some women, as well as minor damage to the cornea and retina. A visit to an opthomologist is recommended when taking tamoxifen to rule out any potential eye problems.
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This conversion is called aromatization and it relies on the action of the enzyme aromatase. Arimidex prevents aromatization by binding to the aromatase.
Arimidex tablets contain the active ingredient anastrozole, which is a type of medicine known as a non-steroidal aromatase inhibitor. It works by preventing the action of an enzyme in the body called the aromatase enzyme.
Potential Arimidex use error: Mixing up products with similar drug names or packaging, taking wrong dose of a drug because of confusing dosing instructions on label.
Options. Posted by Kay on 12 Dec 2011 at 10:34 Am Arimidex gave me severe joint and muscle pain. Changed to tamoxifen and it gave me a blood clot. Changed to Aromasin and suffered joint and muscle pain again but not quite as bad as Arimidex. Night sweats are a big problem along with hair loss. I'M only taking it every other day. My oncologist knows that I'Ve chosen to do this. So far I'Ve not had a recurrence four years from a mastectomy.
I had two hip replacements and feel 20 years younger! Was the loss of cartilege from the Arimidex or chemo? The Dr.S say no. I'M not convinced. I hope that when I stop the Arimidex that I lose a few more pounds and continue to be cancer-free.
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