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If you forget to take a dose of Plavix, but remember within 12 hours of your usual time, take your tablet immediately and then take your next tablet at the normal time. If you forget for more than 12 hours simply take the next single dose at the usual time. Do not take a double dose to make up for the one you missed. You can check the day on which you last took a tablet of Plavix by referring to the calendar printed on the blister strip.
Plavix is used for reducing the risk of stroke or heart attack in patients who have already had a heart attack or stroke, have other circulatory problems caused by narrowing and hardening of the arteries, or have certain other heart problems eg, unstable angina.
Shelling with their own money? Flash back to 75% in the prescription drugs.
Observational studies of the effect of co-administration of a proton pump inhibitor and clopidogrel on cardiovascular outcomes following acute coronary syndromes have had conflicting findings.
As yet, we have no data assuring that prasugrel is safe to use in combination with fibrinolytic agents, so patients on thrombolytic therapy for acute MI should continue to receive clopidogrel starting immediately after lysis. Furthermore, in patients who proceeded to coronary artery bypass grafting, the rate of major bleeding was more than four times higher in the prasugrel group than in the clopidogrel group in the TRITON-TIMI 38 trial.
CYP2C19 poor metabolizer status is associated with diminished response to clopidogrel. The optimal dose regimen for poor metabolizers has yet to be determined. See CLINICAL PHARMACOLOGY: Pharmacogenetics.
Ticlopidine Ticlid, a first-generation thienopyridine, is also a prodrug, but it is unclear to what extent CYP2C19 enzymatic activity is required for its bioactivation. Prasugrel Effient, a third-generation thienopyridine that was recently approved by the FDA, is also a prodrug, but is unique in that its bioactivation appears to be less dependent on CYP2C19 activity. In fact, carriers of the 2 allele produce equivalent concentrations of active metabolite and achieve similar degrees of platelet inhibition compared with noncarriers.
PharmGKB contains no links to external pathways for this drug. To report a pathway, click here.
Autonomic Nervous System Disorders : Syncope, Palpitation. Body as a Whole-general disorders: Asthenia, Fever, Hernia. Cardiovascular disorders: Cardiac failure. Central and peripheral nervous system disorders: Cramps legs, Hypoaesthesia, Neuralgia, Paraesthesia, Vertigo. Gastrointestinal system disorders: Constipation, Vomiting. Heart rate and rhythm disorders: Fibrillation atrial. Liver and biliary system disorders: Hepatic enzymes increased. Metabolic and nutritional disorders: Gout, hyperuricemia, non-protein nitrogen NPN increased. Musculo-skeletal system disorders: Arthritis, Arthrosis. Platelet, bleeding clotting disorders: GI hemorrhage, hematoma, platelets decreased. Psychiatric disorders: Anxiety, Insomnia. Red blood cell disorders: Anemia. Respiratory system disorders: Pneumonia, Sinusitis. Skin and appendage disorders: Eczema, Skin ulceration. Urinary system disorders: Cystitis. Vision disorders: Cataract, Conjunctivitis.
A patient who suffered serious injury after using the popular blood-thinner Plavix has filed the first lawsuit against the drug maker accusing the company of intentionally withholding vital safety information in the name of profit.
Plavix class action suits and individual lawsuits are being reviewed nationwide for users who have suffered serious side effects.
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